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KMID : 0617220030140010119
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Duksung Bulletin Phamaceutical Sciences
2003 Volume.14 No. 1 p.119 ~ p.125
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Anti-inflammatory and Anti-Rheumatoid action of Panax Ginseng Head butanol fraction
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Abstract
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We valuated the Anti-inflammatory and Anti- Rheumatoid action of Panax Ginseng Head butanol(HPGb). Anti-inflammatory activities of ethanol extract of Panax Ginseng head were tested on vascular permeability. Panax Ginseng ethanol extract showed inhibition of vascular permeabiliity by 30.6％. Panax Ginseng ethanol extract was fractionated with hexane, carrageenan-induced paw edema at 0.5, 1, 2 and 3 hr. Butanol fraction (300, 500㎎/㎏) inhibitory activity at carrageenan-induced paw edema were comparable to Anti- inflammatory drug inuprofen. It was also tested on adjuvant-induced arthritis in rats as one of chronic arthritic tests. Butanol fraction showed the inhibition against the swelling of rat paws induced by Mycobacterium tuberculosis at a dose of 500㎎/㎏. Taken together, these result support that HPGb can be applicable for the improvement of arthritic symptoms as a new diet-supplement. HPGb showed low acute toxicitiy with minimum lethal of more than 5,000㎎/㎏, p.o.
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